By Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)
This quantity offers breakthroughs and methods in affinity capillary electrophoresis to degree and make sure the physicochemical and thermodynamic parameters of drug compounds. It discusses recommendations to discover and symbolize interactions to facilitate advancements in managed drug supply and concentrating on.
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Extra resources for Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs)
13. 14. 15. 16. 17. 18. 19. 20. 21. 43 MT Bowser, DDY Chen. Binding constants from rectangular hyperbolae. I: J Phys Chem 102:8063–8071, 1998; II: J Phys Chem 103:197–202, 1999. KL Rundlett, DW Armstrong. Methods for the determination of binding constants by capillary electrophoresis. Electrophoresis 22:1419–1427, 2001. KL Rundlett, DW Armstrong. Methods for estimation of binding constants by capillary electrophoresis. Electrophoresis 18:2194–2202, 1997. MT Bowser, DDY Chen. Higher-order equilibria and their effect on analyte migration behavior in capillary electrophoresis.
Complete Separation of the Equilibrium Mixture In some cases the equilibration rate is very slow compared to the time scale of the analytical separation. The pre-equilibrated reaction mixture behaves indeed as a mixture of inert components and can be separated by capillary electrophoresis. The concentrations are directly derived from the peak areas or peak heights after calibration. This method is suitable if ligand and substrate are separable and the migration time does not exceed 1% of the halflife of complex decomposition.
Therefore, the solutes are ﬁrst separated conventionally by CE. In a second run, the run buffer is doped with a speciﬁc complex-forming substance, and the change in the retention time Principles of Capillary Electrophoresis 19 of the solutes is then recorded. Although, formally MEKC can also be considered an ACE method, where hydrophobic or electrostatic interactions between solute and micelle take place, the term ACE generally seems to be more or less conﬁned to stronger and more speciﬁc interactions with welldeﬁned stoichiometry.
Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics (Drugs and the Pharmaceutical Sciences: a Series of Textbooks and Monographs) by Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)